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You are here: Home / Agenda / Seminars / Like a rolling marble: Waddington’s landscape vibrant legacy and beyond.

Like a rolling marble: Waddington’s landscape vibrant legacy and beyond.

The idea is to bring together various communities, from mathematicians, to biologists, and from physicists to philosophers of science to debate the theoretical fertility and the modelling practices of the Waddington’s landscape concept.
When Nov 07, 2024 09:00 to
Nov 08, 2024 06:30
Where ENS site Descartes - Amphi Descartes
Contact Name
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A two day workshop in Lyon the 7th and 8th of November 2024.

The epigenetic landscape has been introduced by the theoretical biologist Conrad Hal Waddington at the end of the 1930’s as an image in order to represent the process of cellular differentiation during embryonic development.

During the recent years this image has become iconic and massively used throughout several topics of biology, for example in the study of cancerogenesis and of cancer healing, of cellular tensegrity, of evolutionary biology, and in modelling differentiation seen at the single-cell level.

Beyond its very intuitive nature, the success of the “Waddington’s landscape” was also reinforced by recent formal studies showing that departing from its metaphorical aspect, the landscape could be described in mathematical terms under the auspices of dynamical systems theory. It is interesting to note that such a quest for an expression in mathematical terms of the epigenetic landscape accompanied Waddington’s career.

 

By introducing its landscape, Waddington intended not only to integrate development with genetics but also to incorporate them in an evolutionary framework. In this spirit, the aim of this workshop will be to bring together various communities, from mathematicians, to biologists, and from physicists to philosophers of science to debate the fertility of the landscape concept as well as to address open conceptual and modelling questions.


Programme

Thursday, November 7, 2024

Time Event  
14:00 - 14:30 An introduction to the workshop - Sara Franceschelli, Olivier Gandrillon, Sophie Pantalacci  
14:30 - 15:15 With or without an epigenetic landscape? Waddington versus Schmalhausen about genetic assimilation - Laurent Loison  
15:15 - 16:00     
Waddington’s Epigenetic Landscape: How catastrophes may explain Goldschmidt’s “Hopeful Monsters” hiding in the Adjacent Possible - Sui Huang  
16:00 - 16:45 Coffee break  
16:45 - 17:30 TBD - SP3  


Friday, November 8, 2024

Time Event  
09:00 - 09:45     
TBD - SP4  
09:45 - 10:30 Stability/Flexibility: the tightly coupled homeostasis generator is at the same time the driver of change - Alessandro Giuliani  
10:30 - 11:00 Coffee break  
11:00 - 11:45 TBD - SP6  
11:45 - 14:00 Lunch  
14:00 - 14:45 TBD - SP7  
14:45 - 15:30 TBD - SP8  
15:30 - 16:00 Coffee break  
16:00 - 17:00 Round Table




Organisat·eur·rices

  • Sara Franceschelli, ENS de Lyon, IXXI
  • Olivier Gandrillon, ENS de Lyon, IXXI, BioSyL
  • Sophie Pantalacci, ENS de Lyon, IXXI, BioSyL

More information about this event…